Benchling Integration

When to use

Use this skill for Benchling registry entities, sequence imports, inventory, ELN entries, workflow tasks, apps, event-driven integrations, and warehouse analytics.

Reviewed 2026-09-30: examples target the released benchling-sdk 1.25.0 and its stable v2 API models. The current authentication guide recommends V3 for new development, while the V3 guide still describes endpoint-specific early access. Confirm your tenant's V3 availability and stability before migrating; these v2 SDK examples must not be mechanically rewritten to V3.

SDK imports, model serialization, and request construction were checked locally against 1.25.0. Tenant-dependent examples are illustrative: no authenticated requests, mutations, AWS deployment, or warehouse connection were run.

Workflow

1. Identify the tenant, API version, identity, and permissions. Use OAuth app credentials for background integrations; use delegated authorization when acting as an individual user. See authentication.
2. Read the relevant schema and resolve actual folder, registry, status, and dropdown IDs. Preserve sequence alphabet/topology and sample units. A valid Python model does not establish biological correctness or satisfaction of a tenant's required fields.
3. Read a small filtered page before writing. Use typed SDK methods and check their actual parameter names; not all services share the same CRUD naming convention.
4. Construct and serialize a representative payload. For imports, retain external IDs and returned Benchling IDs so a retry can reconcile a partial run without duplicates.
5. Perform the requested operation and read back the result. Check terminal async status; completed polling can still mean FAILED.

Setup and a read-only query

uv pip install "benchling-sdk==1.25.0"

import os
from benchling_sdk.benchling import Benchling
from benchling_sdk.auth.client_credentials_oauth2 import ClientCredentialsOAuth2

tenant_url = os.environ["BENCHLING_TENANT_URL"].rstrip("/")
benchling = Benchling(
    url=tenant_url,
    auth_method=ClientCredentialsOAuth2(
        client_id=os.environ["BENCHLING_CLIENT_ID"],
        client_secret=os.environ["BENCHLING_CLIENT_SECRET"],
        token_url=f"{tenant_url}/oauth/token",
    ),
)
for page in benchling.dna_sequences.list(page_size=10, name_includes="plasmid"):
    for sequence in page:
        print(sequence.id, sequence.name)
    break  # deliberate first-page connectivity/permission check

A successful empty page is a valid connectivity result. It does not imply access to all projects. There is no documented v2 users/me route or SDK users.get_me().

Important SDK conventions

• Import fields from benchling_sdk.helpers.serialization_helpers. Its input is {"field_name": {"value": value}}, including the inner value mapping.
• Use dna_sequence_id for DNA updates and workflow_task_id for workflow updates. Workflow task creation requires a workflow_task_group_id.
• Entry methods are create_entry, get_entry_by_id, list_entries, and update_entry.
• list() usually returns pages; iterate twice to reach the objects. estimated_count is a property that can raise NotImplementedError, not a method or guaranteed count.
• Moving a tube uses ContainerUpdate(parent_storage_id=...). Material transfer is a separate operation; it changes contents and quantities.
• Register on creation with registry_id plus either entity_registry_id (a human registry identifier) or naming_strategy. Do not confuse those with the registry's ID.

Common use cases

Import FASTA sequences

Install Biopython separately (uv pip install biopython). This illustrative import creates unregistered linear DNA; choose topology and resolve collisions before running.

from Bio import SeqIO
from benchling_sdk.models import DnaSequenceCreate

for record in SeqIO.parse("sequences.fasta", "fasta"):
    payload = DnaSequenceCreate(
        name=record.id,
        bases=str(record.seq),
        is_circular=False,
        folder_id="lib_example",
    )
    created = benchling.dna_sequences.create(payload)
    print(record.id, created.id)  # persist this mapping for restart/reconciliation

Audit inventory under a location

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